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Reanalysis of JAACAP Study on Paroxetine Sparks Controversy

A reanalysis of data from a 2001 study that concluded paroxetine to be generally well tolerated and effective for treating major depression in adolescents has raised questions over the safety and effectiveness of the drug in this patient population, according to a paper published Wednesday in the BMJ.The original study, published in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), describes an eight week, double-blind randomized control trial that compared the safety and effectiveness of paroxetine (20 mg to 40 mg) and imipramine (gradual upward titration...

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Published By: Psychiatric News - Thursday, 17 September, 2015

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